The Role of Macrophages in Staphylococcus aureus Infection

Staphylococcus aureus is a member of the human commensal microflora that exists, apparently benignly, at multiple sites on host. However, as an opportunist pathogen it can also cause range serious diseases. This requires ability to circumvent innate immune system establish infection. Professional phagocytes, primarily macrophages and neutrophils, are key cells which interact with S. , acting gatekeepers contain resolve Recent studies have highlighted important roles during infections, using wide array killing mechanisms. In defense, has evolved strategies survive within, manipulate escape from macrophages, allowing them not only subvert but exploit this element our system. Macrophage- interactions multifaceted direct in infection outcome. depth understanding these host-pathogen may be useful for future therapeutic developments. review examines macrophage throughout all stages infection, special emphasis mechanisms determine